7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.
Identifieur interne : 000050 ( France/Analysis ); précédent : 000049; suivant : 0000517 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.
Auteurs : Stéphane Lehéricy [France] ; Eric Bardinet ; Cyril Poupon ; Marie Vidailhet ; Chantal FrançoisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
Abstract
A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (SN) directly. Histologically, the SN is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. In humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the SN pars reticulata (SNr). The SNr contains higher levels of iron than the SNc in normal subjects. Neuromelanin and T2*-weighted imaging therefore better detect the SNc and the SNr, respectively. The development of ultra-high field 7 Tesla (7T) magnetic resonance imaging (MRI) provided the increase in spatial resolution and in contrast that was needed to detect changes in SN morphology. 7T MRI allows visualization of nigrosome-1 as a hyperintense signal area on T2*-weighted images in the SNc of healthy subjects and its absence in PD patients, probably because of the loss of melanized neurons and the increase of iron deposition. This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organization of the SN. The recent findings obtained at 7T will then be presented in relation to histological knowledge.
DOI: 10.1002/mds.26043
PubMed: 25308960
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000362
- to stream PubMed, to step Curation: 000362
- to stream PubMed, to step Checkpoint: 000710
- to stream Ncbi, to step Merge: 004142
- to stream Ncbi, to step Curation: 004142
- to stream Ncbi, to step Checkpoint: 004142
- to stream Main, to step Merge: 000690
- to stream Main, to step Curation: 000690
- to stream Main, to step Exploration: 000690
- to stream France, to step Extraction: 000050
Links to Exploration step
pubmed:25308960Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.</title><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stéphane" last="Lehéricy">Stéphane Lehéricy</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name></author><author><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25308960</idno><idno type="pmid">25308960</idno><idno type="doi">10.1002/mds.26043</idno><idno type="wicri:Area/PubMed/Corpus">000362</idno><idno type="wicri:Area/PubMed/Curation">000362</idno><idno type="wicri:Area/PubMed/Checkpoint">000710</idno><idno type="wicri:Area/Ncbi/Merge">004142</idno><idno type="wicri:Area/Ncbi/Curation">004142</idno><idno type="wicri:Area/Ncbi/Checkpoint">004142</idno><idno type="wicri:Area/Main/Merge">000690</idno><idno type="wicri:Area/Main/Curation">000690</idno><idno type="wicri:Area/Main/Exploration">000690</idno><idno type="wicri:Area/France/Extraction">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.</title><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stéphane" last="Lehéricy">Stéphane Lehéricy</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name></author><author><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Parkinson Disease (pathology)</term><term>Substantia Nigra (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (SN) directly. Histologically, the SN is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. In humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the SN pars reticulata (SNr). The SNr contains higher levels of iron than the SNc in normal subjects. Neuromelanin and T2*-weighted imaging therefore better detect the SNc and the SNr, respectively. The development of ultra-high field 7 Tesla (7T) magnetic resonance imaging (MRI) provided the increase in spatial resolution and in contrast that was needed to detect changes in SN morphology. 7T MRI allows visualization of nigrosome-1 as a hyperintense signal area on T2*-weighted images in the SNc of healthy subjects and its absence in PD patients, probably because of the loss of melanized neurons and the increase of iron deposition. This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organization of the SN. The recent findings obtained at 7T will then be presented in relation to histological knowledge.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></noCountry><country name="France"><noRegion><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stéphane" last="Lehéricy">Stéphane Lehéricy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000050 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000050 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:25308960
|texte= 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:25308960" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |